If anyone can do it this season its surely the Pats... I wouldn't say that they have had a very difficult schedule though. And running up the score on every opponent to say "Fuck you" is definitely giving them really bad karma. The Colts certainly have a shot to knock off the Pats but I'd put my money on NE this week.
However, since Brady is on my fantasy team, they can go 16-0 for all I care as long as he's giving 3-5 TD's a game.